Hypostatic, hypostasis, or hypostatization (hypostatisation; from the Ancient Greek ὑπόστᾰσις, "under state") may refer to:

• Hypostasis (philosophy and religion), the essence or underlying reality
• Hypostatic abstraction (mathematics and logic)
• Hypostasis of the Archons, a Gnostic work
• Hypostasis (linguistics), personification of entities
• Hypostasis (literature), awareness by a fictional character that their world is fictional
• Hypostatic gene, as a result of epistasis
• Hypostasis (livor mortis), corpse's discoloration
• Hypostatic model of personality, a psychological model, or theory, of personality masks
• Hypostatic union, Christian concept
• Holding current (electronics), or the hypostatic current
• Reification (fallacy), where hypostasis identifies a reified thing, and hypostatization refers to the thought process
• Sediment in a liquid, including:
  • Sediment#Dregs
• A type of boss enemy in the video game Genshin Impact